That depend on mutant p53 expression by the activation of chaperone-mediated autophagy and potential pharmacological means Taken together, our results delineate a novel strategy for killing tumor cells In addition, depletion of mutant p53 expression due to macroautophagy inhibition sensitizes the death of dormantĬancer cells under nonproliferating conditions. Macroautophagy by multiple means promotes the degradation of mutant p53 through chaperone-mediated autophagy in a lysosome-dependentįashion. In nonproliferating tumor cells using a combination of pharmacological and genetic approaches. Here we investigated the mechanisms that govern the turnover of mutant p53 Thus, promoting the removal of mutant p53 proteins inĬancer cells may have therapeutic significance. Accumulated mutant p53 proteinsĪre known to actively contribute to tumor development and metastasis. Missense mutations in the gene TP53, which encodes p53, one of the most important tumor suppressors, are common in human cancers. 10Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), 75015 Paris, France.9Centre de Recherche des Cordeliers, 75006 Paris, France.8Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.7Metabolomics Platform, Institut Gustave Roussy, 94805 Villejuif, France.6Institut Gustave Roussy, 94805 Villejuif, France.5U848, Institut National de la Santé et de la Recherche Médicale (INSERM), 94805 Villejuif, France.4Braman Family Breast Cancer Institute, Miller School of Medicine, University of Miami, Florida 33136, USA.3Department of Pathology, Interdisciplinary Stem Cell Institute,.2Shanghai Institute of Organic Chemistry, Shanghai 200032, China.1Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
0 kommentar(er)
